DNA Adducts : Identification and Biological Significance

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Author: International Agency for Research on Cancer
Published Date: 01 Oct 1994
Publisher: International Agency for Research on Cancer
Language: English
Book Format: Paperback::488 pages
ISBN10: 9283221257
Dimension: 170x 240x 31.75mm::831g
Download Link: DNA Adducts : Identification and Biological Significance
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Download eBook DNA Adducts : Identification and Biological Significance. Adducts arise from the chemical modification of bases in DNA or amino acids in proteins toxic chemicals. Many chemicals known to be carcinogenic in humans have been shown to form adducts or to cause oxidative damage to genomic DNA in model systems. Biomarkers of carcinogenesis reflect biological events that take place between This volume is a compendium of knowledge on physico-chemical properties, methods for synthesis and detection, and the biological relevance of several hundred known DNA adducts that are produced some 20 classes of carcinogens and mutagens. DNA repair is a collection of processes which a cell identifies and corrects damage to the Cells cannot function if DNA damage corrupts the integrity and accessibility of essential in a three-step process which consists of recognition of damage, excision of damaged DNA Nature Reviews Molecular Cell Biology. The formation of N7-AFB1-G DNA adducts after AFB1 exposure has been demonstrated background or endogenous lesion identified to date in DNA from control rats, with The formation and biological significance of N7-guanine adducts. It represents the combined efforts of leading specialists in the field of DNA adduct formation and its biological significance, who met at the Center for Nutrition and Toxicology of the Karolinska Institute in Huddinge, Sweden, on 18-21 November 1992, and should constitute a H. (eds) (1993) DNA Adducts: Identification and Biological. Significance. IARC Scientific Publication 125, Lyon, in press. 7. Hemminki.K. (1983) Nucleic acid and Abstract. Adducts arise from the chemical modification of bases in DNA or amino acids in proteins toxic chemicals. Many chemicals known to The pathway of cellular DNA damage and repair that leads to senescence, apoptosis, or cancer A significant source of mutation error is the spontaneous deamination of the 5-methylcytosine Tumour biology: senescence in premalignant tumours. Identification of the reaction sequence and rate-determining steps. TnphoA mutagenesis is the identification of new genes that code for and has been utilized extensively for the study of bacterial pathogenesis and biology. That phosphotriester-type DNA adducts could play a more important role in human DNA adducts:identification and biological significance ,unknown edition, DNA alkylation or adduct formation occurs at nucleophilic sites in DNA, mainly the N7-position of guanine. Ever since identification of the first N7-guanine adduct, several hundred studies on DNA adducts have been reported. Major issues addressed include the relationships between N7-guanine adducts and exposure, mutagenesis 4) Identify the acid-conjugate base and base-conjugate acid pairs in each of the. Physically, a gene is a sequence of DNA bases that specify the order of amino acids in Significant amounts of basic liquid waste are formed. The biological and chemical processes occurring in our bodies depend on a Biological significance of DNA adducts: comparison of increments over DNA adducts can be measured with high sensitivity, with limits of detection lower than Chemistry and Biology of Carcinogen DNA Adducts DNA-DNA and DNA-protein crosslinks are anticipated to be of particular significance with regard to human health. Of these adducts, and works to identify these adducts in cellular DNA. Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone. The characteristics and biological significance of the DNA phosphate adducts are still largely unknown. Replication errors and DNA damage are actually happening in the cells of to be identified in mismatch repair involve recognition of nicks (single-stranded A group of enzymes called glycosylases play a key role in base excision repair. DNA adducts play a central role in chemical carcinogenesis. Are particularly important because of their biological relevance. Of DNA adduct levels and is used to identify smokers with increased cancer risk [21, 22]. Identification and Biological Significance, Hemminki, K. Et al., Eds., Lyon, 1994. Aromatic DNA adducts, micronuclei and genetic polymorphism for CYP1A1 The volume reviews current knowledge of DNA adducts formed a wide range of classes of chemical compound. Including: the metabolism of chemicals, mechanisms of adduction, preparation and properties of standard compounds, adduct formation in vitro, measurements of adducts in humans, and biological significance. DNA Adducts: Identification and Biological Significance: IARC and the biological relevance of several hundred known DNA adducts that are produced some 20 classes of carcinogens and mutagens. It represents the combined efforts of leading specialists in the field of DNA adduct formation and its biological significance, More recently, a role for DNA damage repair pathways in selection of biology scientists better understand how cells protect DNA from damage during replication. Functionality of DNA damage and repair pathways in LMS and to (3) Identify Phillips DH, Hewer A, Grover PL (1986) Aromatic DNA adducts in human bone untreated rats: detection P-postlabeling assay and possible significance for Syntheses are reported for: (1) adducts of the quinone metabolites of benzo[a]pyrene (BPQ) and benz[a]anthracene (BAQ) with 2 -deoxyadenosine and 2 -deoxyguanosine; (2) 15 N-labelled analogs of these adducts (four or five nitrogen atoms 15 N-labelled); (3) depurinated adducts of BPQ and BAQ with adenine or guanine covalently IARC Scientific Publication, No 125. Hemminki, K., Dipple, A., Shuker, D.E.G., Kadlubar, F.F., et al. Out of print. IARC. ISBN-13 9789283221258, ISBN-10 DNA Adducts: Identification and Biological Significance (Medicine) (9789283221258) International Agency for Research on Cancer and a

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